This monoclonal antibody provides highly specific detection of Tau phosphorylated at threonine‑231 (pTau‑231), a phosphorylation site linked to early Alzheimer’s pathology and synaptic dysfunction. Clone 100 delivers strong affinity and minimal nonspecific binding, supporting ELISA, Western blotting, immunohistochemistry, and biomarker assay development. MT231‑80A‑100 is ideal for studies examining Tau misfolding, phosphorylation kinetics, and early‑stage neurodegenerative changes. Its consistent lot‑to‑lot performance ensures reliable detection across CSF, plasma, and tissue‑based research samples.